SynChrom R&D

PET-automatic-synthesis-unit for nucleophilic substitution

Applications

PET synthesis of:

FEC

FLT

FET

F-Miso

F-Altanserin

FDG

others

The SynChrom R&D system has been developed & designed to afford the transfer of the radio chemist’s idea of a chemical synthesis process from an “on hand”, published or known process to a fully automatic synthesis system. Also the entire chemical process development can be done on this unit. Almost all synthesis processes can be applied.

With the optional reactor pre-cooling device even electrophilic substitution processes can be adapted.

The SynChrom R&D unit is equipped with one or two unique raytest transparent reactor systems. The entire process is visible. The 500W electrical air heater system & the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20°C -/+180°C. SynChrom R&D is equipped with very fast, low dead volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination.

The built-in pressure sensor continuously displays the actual system (reactor) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected “accidents” with selectable warning and shutdown levels. The reactor system is also equipped with a magnetic stirrer mixing system & a tube lifting system.

The unit contains a built-in lead shielded housing for the F-trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without a on site cyclotron). The target delivery can be done directly to the F-trap or via the target vial.

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