PET-automatic-synthesis-unit for FDG production
The SynChrom FDG system has been developed & designed to produce [18F]-FDG based on nucleophilic substitution. The system is based on the raytest SynChrom R&D system without the hardware which is not required for the FDG synthesis process. raytest is supplying the entire process documentation as well as the responsibility for the successful FDG production on this device.
The SynChrom FDG unit is equipped with one of the unique raytest transparent reactor systems. The entire process is visible. The 500W electrical air heater system & the compressed air cooling enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range 20°C - +180°C. SynChrom FDG is equipped with very fast, low hold up volume, solvent resistant and pressure tight ( 4 bars ) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination.
The built-in pressure sensor continuously displays the actual system ( reactor ) pressure. This pressure sensor is also used for automatic gas leakage test after the synthesis unit cleaning procedure. During the process this sensor also observes the process for unexpected “accidents” with selectable warning and shutdown levels. The reactor system is also equipped with a magnetic stirrer mixing system & a tube lifting system.
The unit contains a built-in lead shielding housing for the F-trap as well as a shielded target water collecting vial with radiation detectors for observation, analysis and reporting. (both can be used also without a self owned cyclotron). The target activity delivery can be done directly to the F-trap or via the target vial.