SynChrom F2

PET-automatic-synthesis-unit for electrophilic substitution

Applications

PET synthesis of:

F-DOPA

F-Tyrosine

F-Uracile

SynChrom F2 is a fully automatic PET-synthesis unit for electrophilic substitution processes. 

The system contains the unique raytest transparent reactor system. The entire process is visible.

The first synthesis step requires a very low temperature. SynChrom F2 has a nitrogen gas cooled (liquid nitrogen pre cooled) reactor and a 500W electrical air heater. This enables ultra fast temperature changes in the synthesis reagent solvent. The system monitors the real solvent temperature. Temperature range –40°C - +180°C

SynChrom F2 is equipped with very fast, low hold up volume, solvent resistant and pressure tight (4 bars) magnetic flipper valves. All solvents are transported directly into the reactor vessel, without any solvent cross contamination. The built-in pressure sensor displays the actual system (reactor) pressure. This pressure sensor is also used for pressure / vacuum tightness test after the synthesis unit cleaning procedure. During the process this sensor also observes for unexpected events with settable warnings and shutdown levels. 

The 18ml reactor is equipped with a magnetic stirrer solvent mixing system and a tube lifting system.

The reactor is equipped with a lead shielded radiation detector to monitor the actual delivered activity and to automatically calculate the yield. (EOB / EOS).

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